Calico describes a coat, not a breed: white with patches of black and orange, or soft gray and cream in the dilute version. The pattern appears in domestic shorthairs and longhairs and in many pedigreed breeds. Because the orange and black color genes ride on the X chromosome, nearly all calicos are female, and the rare males are typically sterile.
In Louisville, most calicos you meet are domestic shorthairs, so size, coat and health look like those of any house cat, usually 6 to 12 pounds and living 12 to 18 years. Folklore credits calicos with sass, but coat color hasn't been shown to predict personality. Spending time with a cat and watching how she handles people and other pets tells you far more than her patches do.