Calico is a coat pattern rather than a breed: white with patches of orange and black, or gray and cream in the dilute version. It appears on domestic shorthairs and longhairs and on many pedigreed breeds, so size and fur vary. Most adoptable calicos are shorthaired house cats weighing roughly 6 to 12 pounds, and many live 12 to 18 years indoors.
Care looks like care for any house cat: vaccines, dental checks, weight control and steady play. In Birmingham's humid, mild-winter climate, a vet can help you plan flea and tick prevention. Coat color doesn't predict personality, so spend time with the cat you're considering and see how she handles people, noise and other pets.