Calico is a coat pattern, not a breed: white with patches of black and orange, or soft gray and cream in the dilute version. The pattern appears in domestic shorthairs and longhairs and in several pedigreed breeds. Because the genes for orange and black sit on the X chromosome, nearly all calicos are female, and the rare males are typically sterile.
Most calicos are domestic shorthairs, medium cats of roughly 6 to 12 pounds who live 12 to 18 years indoors. That means moderate shedding, ordinary cat care and a personality shaped by upbringing rather than color. Folklore about calico attitude hasn't held up in research, so judge each cat by how she handles people, noise and other pets.