Calico is a coat pattern, not a breed: white with patches of black and orange, or gray and cream in the dilute version. It shows up in domestic shorthairs, longhairs and many pedigreed breeds, so size, coat length and energy vary from cat to cat. Nearly all calicos are female, and most weigh somewhere between 6 and 12 pounds.
Most calicos waiting for adoption are domestic shorthairs, so their care looks like any house cat's: vaccines, dental care, weight control and a few good scratching posts. Folklore credits them with attitude, but coat color doesn't reliably predict personality. In a Kansas City home, how a cat reacts to noise, visitors and other pets matters far more than her patches.