Calico describes color, not ancestry: white with patches of black and orange, or gray and cream in the dilute version. The pattern shows up in domestic shorthairs, longhairs and several pedigreed breeds, and nearly all calicos are female because the orange and black color genes sit on the X chromosome. Most adoptable calicos are domestic shorthairs, typically 6 to 12 pounds, and many live 12 to 18 years indoors.
That mixed ancestry means care looks like any house cat's: vaccines, dental care, weight control and regular play. A shorthaired calico needs a weekly brushing, while a longhaired mix may need it more often in humid weather to keep mats from forming. Coat color doesn't predict temperament, so spend time with a cat and see how she handles people and other pets before deciding.